By Kasugai, Yu; Machtoub, Lina
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Additional info for Amyotrophic lateral sclerosis : advances and perspectives of neuro-nanomedicine
Experimental Brain Research (2006), 172:361–369. Copyright 2006, Springer Science. The motor execution in ALS has been also associated with increased activations of areas involved in motor learning, such as the basal ganglia and the cerebellum. It is suggested that an increase in movement-associated cortical activations beyond the primary motor cortex is associated with the degree of UMN involvement. 2 Electrophysiology in the Revised EEC The revised EEC state that EMG/NCV (nerve conduction velocity) examination is an extension of the clinical examination used to identify LMN dysfunction, which can be deﬁned by electromyographic concentric needle examination to provide evidence of active and chronic denervation.
Typically, CST changes, which are best followed on coronal scans, appear as areas of bilateral increased signal intensity from the centrum semiovale to the brain stem. 4 Conventional MR imaging ﬁndings in patients with ALS. A–D: Hyperintensity at the subcortical precentral gyrus (A and B) and the centrum semiovale (C and D) on FLAIR (arrows A and C) and T2-weighted (arrows B and D) images of a 66-year-old patient with ALS. Modiﬁed with permission from Hecht et al. E and F: T2-weighted images obtained from a 58-year-old patient with ALS with dementia show hypointensity along the precentral cortices (arrowhead E) and symmetric hyperintensity in the anterior temporal subcortical WM (arrow F).
TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis. Science. 2008; 319(5870):1668–1672. 7. Brugman F, Veldink JH, Franssen H, et al. Diﬀerentatiion of hereditary spastic paraparesis from primary lateral sclerosis in sporadic adultonset upper motor neuron syndromes. Arch Neurol. 2009;66:509–514. 8. Pasinelli P, Brown RH. Molecular biology of amyotrophic lateral sclerosis: insights from genetics. Nat Rev Neurosci. 2006;7:710–723. 9. Dion PA, Daoud H, Rouleau GA. Genetics of motor neuron disorders: new insights into pathogenic mechanisms.
Amyotrophic lateral sclerosis : advances and perspectives of neuro-nanomedicine by Kasugai, Yu; Machtoub, Lina