By L. F. Bélanger, T. Semba, S. Tolnai, D. H. Copp, L. Krook, C. Gries (auth.), H. Fleisch, H. J. J. Blackwood, M. Owen (eds.)
The papers amassed during this quantity symbolize the formal court cases of the 3rd ecu Symposium on Calcified Tissues which was once held in Davos, Switzerland from eleventh to sixteenth April 1965 less than the sponsorship of the Laboratorium fur experi mentelle Chirurgie, Schweizerisches Forschungsinstitut Davos. This Symposium fol lowed the now demonstrated culture of the former Symposia held in Oxford in 1963 and in Liege in 1964. Participation used to be back strictly on a residential foundation. This yr the Schatz alp resort supplied a scenic and secluded assembly position excessive on a mountain facet overlooking Davos but with regards to the Forschungsinstitut within which the hole consultation of the Symposium used to be held. The papers and communications released within the quantity are prepared so as of presentation and are grouped below the 5 major subject matters chosen for dialogue via the Symposium, specifically, "Cell functionality within the formation, upkeep and destruc tion of osseous tissue", "Response of calcified tissues to mechanical factors", "Mecha nisms of mineralization and ailments relating to mineral deposition", "Hormones and bone" and "Fundamental constitution of dental demanding tissues". The programme consisted of a couple of evaluate lectures given by means of invited audio system and of brief communications when it comes to all of the above subject matters. No test was once made to checklist the dis cussions to the papers as, being a residential assembly, the extra invaluable and curiosity ing interchanges happened informally in small chat groups and never in the time time table of the prearranged programme.
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Extra resources for Calcified Tissues 1965: Proceedings of the Third European Symposium on Calcified Tissues held at Davos (Switzerland), April 11th–16th, 1965
It has to be distinguished from another pool (NMll ) larger in size but labelled much later. The more organized collagen which is not extractable under our experimental conditions, (12)' comes next in the metabolic chain. It has to be differentiated from the very small but highly radioactive collagen bound to the microsomes in cells (I1) which is not extractable. The acid extractable collagen (A) always has the lowest specific activity among all the fractions. It might derive from the 12 pool. Although the proposed scheme is based on the analysis of isotope dilution experiments, it remains partly hypothetical because it has not yet been possible to separate the different pools of molecules forming each fraction.
M. LAPIERE Fractionation studies of soft and calcified tissues separate the collagen in fractions of different organization according to their age. These fractions seem to be related one to the other in a process of maturation quite similar in both tissues. Enzymatic breakdown of the collagen in skin and bone is demonstratable in tissue culture. There exists identical difficulty in isolating a collagenolytic enzyme from living soft and calcified connective tissues. S. Public Health Service. The author wishes to acknowledge the many valuable discussions with DRS.
307. -, and CH. M. LAPIERE: Collagenolytic activity in amphibian tissues: A tissue culture assay. Proc. nat. Acad. Sci. 48, 1014 (1962). HANCOX, N. , and B. BOOTHROYD: Structure-function relationships in the osteoclast. In Mechanisms of Hard Tissue Destruction. SOGNNAES, R. J. ). Washington: Amer. Ass. Advanc. Sci. 1963, p. 497. Remodelling of the Bone Matrix 31 HARKNESS, R. : Biological functions of collagen. BioI. Rev. 36, 399 (1961). -, A. M. MARKO, H. M. MUIR, and A. NEUBERGER: The metabolism of collagen and other proteins of the skin of rabbits.
Calcified Tissues 1965: Proceedings of the Third European Symposium on Calcified Tissues held at Davos (Switzerland), April 11th–16th, 1965 by L. F. Bélanger, T. Semba, S. Tolnai, D. H. Copp, L. Krook, C. Gries (auth.), H. Fleisch, H. J. J. Blackwood, M. Owen (eds.)