Download e-book for iPad: Clinical Nuclear Medicine Fourth Edition by Cook, Gary J.R

By Cook, Gary J.R

ISBN-10: 0340812397

ISBN-13: 9780340812396

ISBN-10: 1444113577

ISBN-13: 9781444113570

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The principal issues under development for functional imaging with MRI and MRS are the ability to quantify functional information, and the specificity for cellular processes. 50 High 12 Molecular imaging resolution images also allow unprecedented detail of organs such as CT colonography. g. luciferase) can also be evaluated with this technique. This allows detection of cellular trafficking in vivo, and assessment of therapeutic interventions, without radiation exposure. Recent developments in instrumentation have resulted in improvements in depth of field and image resolution which have limited photonic detection techniques in the past.

Co-registered (c) 18F-FDG PET/CT and (f) 18F-FLT PET/CT images are also shown. 10 Molecular imaging of glioma. A 56-year-old man with glioblastoma multiforme in the left temporal lobe on MRI (c, arrow) underwent 18F-FDG PET (a, arrow) which showed increased metabolic activity at the tumor margins. PET imaging with 18F-FMISO, a hypoxic tissue marker (b, arrow) indicates significant tumor hypoxia along the medial temporal margin of the tumor. 11 Hypoxia imaging of lung cancer. A 63-year-old woman with newly diagnosed left lung carcinoma on CT scan (a, d) underwent 18F-FDG PET which showed intense uptake in the tumor mass (e).

123I]iodoamphetamine, 99mTcethylenecysteinediamine) and more recently glucose metabolism (18F-FDG). This has only been augmented by the European availability of 123I-ioflupane (DATScan, Amersham plc) since 2000. 24,98 Functional MRI (fMRI) has become ascendant in studies that require repeated examinations in a short period of time or high anatomical resolution. 100 It is likely that optimum imaging solutions for some biological problems will involve a combination of modalities. The specific applications of molecular imaging in neurology can be conceptualized in the following categories: • • • • • • • • • • Neurobiology and neuropathology Psychiatry Neuropharmacology Drug abuse and dependency Epilepsy Neurodegenerative conditions Dementing illnesses Movement disorders Brain ischemia Traumatic brain injury Several characteristics of an imaging ligand are of particular interest when selecting agents for use in neurology, including potency, toxicity, plasma protein binding, penetration of the blood–brain barrier and the specific activity (and hence administered mass).

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Clinical Nuclear Medicine Fourth Edition by Cook, Gary J.R


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