By Ravin Narain
Polymers and Nanomaterials for Gene Therapy presents the most recent details on gene remedy, a subject matter that has attracted major consciousness over the last twenty years for the remedy of inherited and purchased genetic illnesses. significant learn efforts are presently fascinated by designing compatible provider vectors that compact and safeguard oligonucleotides for gene therapy.
The publication explores the latest advancements within the box of polymer technology and nanotechnology, and the way those developments have helped within the layout of complicated fabrics. Non-viral vector structures, together with cationic lipids, polymers, dendrimers, peptides and nanoparticles, are power routes for compacting DNA for systemic supply. in spite of the fact that, not like viral analogues that experience no trouble in overcoming mobile obstacles and immune safety mechanisms, non-viral gene companies continuously convey major decreased transfection potency because of a variety of additional- and intracellular stumbling blocks. consequently, biocompatibility and strength for large-scale creation make those compounds more and more beautiful for gene therapy.
This ebook comprises chapters at the engineering of polymers and nanomaterials for gene treatment, and the way they could shape complexes with DNA and stay away from either in vitro and in vivo boundaries. different chapters describe in vitro, ex vivo, in vivo gene treatment reviews, and the present concerns affecting non-viral gene therapy.
- Explores present demanding situations within the learn of genetic diseases
- Discusses polymers for gene treatment and their functionality in designing complicated fabrics
- Provides examples of natural and inorganic nanomaterials for gene therapy
- Includes labeling, focusing on, and assays
- Looks at characterization, physico-(bio)chemical homes, and applications
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Extra resources for Polymers and Nanomaterials for Gene Therapy
Nat Rev Drug Discov 2008;7:771–82.  Wolfert MA, Seymour LW. Atomic force microscopic analysis of the influence of the molecular weight of poly(L)lysine on the size of polyelectrolyte complexes formed with DNA. Gene Ther 1996;3:269–73.  Tang MX, Szoka FC. The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes. Gene Ther 1997;4:823–32.  Mounkes LC, Zhong W, Cipres-Palacin G, Heath TD, Debs RJ. Proteoglycans mediate cationic liposome-DNA complex-based gene delivery in vitro and in vivo.
22 Polymers and Nanomaterials for Gene Therapy  Isner JM. Arterial gene transfer of naked DNA for therapeutic angiogenesis: early clinical results. Adv Drug Deliv Rev 1998;30:185–97.  Losordo DW, Vale PR, Symes JF, Dunnington CH, Esakof DD, Maysky M, et al. Gene therapy for myocardial angiogenesis: initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia. Circulation 1998;98:2800–4.  Smith BF, Baker HJ, Curiel DT, Jiang W, Conry RM.
Trends Cell Biol 2001;11:385–91.  Wang G, Moniri NH, Ozawa K, Stamler JS, Daaka Y. Nitric oxide regulates endocytosis by S-nitrosylation of dynamin. Proc Natl Acad Sci U S A 2006;103:1295–300.  Subtil A, Gaidarov I, Kobylarz K, Lampson MA, Keen JH, McGraw TE. Acute cholesterol depletion inhibits clathrin-coated pit budding. Proc Natl Acad Sci U S A 1999;96:6775–80. 26 Polymers and Nanomaterials for Gene Therapy  Martin ME, Rice KG. Peptide-guided gene delivery. AAPS J 2007;9:E18–29.
Polymers and Nanomaterials for Gene Therapy by Ravin Narain